The U.S. Chamber of Commerce, which has already been plenty active in promoting its legislative and electoral preferences, has launched a new $10 million ad campaign targeting “12 House and eight Senate races as part of an effort referred to internally as ‘Advance and Protect’,” the Wall Street Journal reports.

Most of the Senate races targeted by the Chamber are those Republicans hope will bring them the four seats needed to win control, including in Wisconsin and Missouri where Republicans haven’t even picked a candidate. The ads in those states, which criticize Rep. Tammy Baldwin of Wisconsin and Sen. Claire McCaskill of Missouri, are designed to weaken the Democratic candidate.

“We don’t want to leave any seats on the table like we did in the last election,” said Scott Reed, one of the Chamber’s advertising strategists.

The ads, via Politico’s Morning Score:

And this is just the beginning. The Chamber dropped $33 million on the 2010 midterm elections, so there’s no telling what it will pony up this election cycle

Regardless, it will definitely be the U.S. Chamber of Horrors for Democrats over the next nine months.