Back in September the U.S. Chamber of Commerce jumped into the 2012 election with a print ad framed as an Open Letter to Congress and President Obama:

(Actually readable version here.)

Now comes a TV campaign (via Politico’s Playbook):

The U.S. Chamber of Commerce launched six new television ads today to ensure that voters are educated on important issues affecting the economy. The ads will air on network and cable in 15 markets across six states, including Iowa, Montana, Nevada, Ohio, Pennsylvania, and Washington. … The six ads can be viewed here.” http://bit.ly/v7iGZL

Representative sample, attacking Ohio Sen. Sherrod Brown (D-I Unemployed My Wife):

The Chamber dropped $33 million on the 2010 midterm elections, so there’s no telling what it will pony up this election cycle.

Safe to say, though, it’ll be a lot more.